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KMID : 0880520090450030154
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Chonnam Medical Journal
2009 Volume.45 No. 3 p.154 ~ p.160
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Clinical Correlation of CD4+CD25+ Regulatory T Cells in Early Immune Reconstitution after Myeloablative Allogeneic Stem Cell Transplantation
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Yang Deok-Hwan
Park Jung-Sun
Ahn Jae-Sook
Kim Yeo-Kyeoung
Lee Je-Jung
Kim Hyeoung-Joon
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Abstract
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We investigated whether CD4+CD25+ regulatory T cells (Tregs) not only reduce the incidence of acute graft-versus-host disease (aGVHD) but also inhibit the expression of NK cells during early immune reconstitution after allogeneic myeloablative hematopoietic stem cell transplantation (HSCT). In addition, we evaluated whether Tregs were associated with disease relapse. Twenty-nine patients underwent non-T cell-depleted allogeneic HSCT. Peripheral blood mononuclear cells (PBMCs) were separated at 3 weeks after HSCT. Fourteen patients developed grade 2-4 aGVHD and 13 patients relapsed. Patients with grade 2-4 aGVHD (median, 5.36 ng/μl) had significantly lower levels of FOXP3 gene expression than did those with grade 0-1 aGVHD (median, 7.45 ng/μl). However, the level of FOXP3 gene expression in patients with relapse (median, 7.46 ng/μl) was significantly higher than in those (median, 5.52 ng/μl) without relapse (P=0.02). However, we did not find an inverse correlation between the expression of NK cells and Tregs. The level of FOXP3 expression in CD4+CD25+ Tregs was related with the incidence of aGVHD and was associated with the risk of disease relapse. However, NK cells showed no correlation with the expression of Tregs during early immune reconstitution after myeloablative HSCT.
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KEYWORD
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Stem cells, Graft-vs-host disease, Gene expressions
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